2006 – 2012

2010

Prof Timothy Cox & Dr Patrick Deegan £31,318Addenbrookes Hospital, University of Cambridge, England
Year two of an 18 month extension grant to establish what lies at the core of the difference between two x-linked lysosomal storage disorders, MPSII, Hunter disease, and Fabry disease, by determining why females harbouring one copy of the defective gene for MPSII almost never develop the condition, whereas females carrying a single Fabry disease gene nearly always suffer from the disorder.

Dr Brian Bigger £156,750MPS Stem Cell Research Group, University of Manchester, UK
A one year grant to study Genistein and synaptic decline in MPS IIIB. This grant includes the cost of a technician, senior post doc researcher and animals, consumables and equipment and a £4000 travel grant.

Dr Brian Bigger £7,000MPS Stem Cell Research Group, University of Manchester, UK
To investigate the hypothesis that brain degeneration in MPS III, Sanfilippo mice is reversible after long-term substrate reduction therapy.

Dr Brian Bigger £6,000MPS Stem Cell Research Group, University of Manchester, UK
To investigate the effect of heparan sulphate on stem cell homing and engraftment on MPS I.

Dr David Begley £20,000Kings College London, UK
A grant to provide six month’s funding to support the cost of maintaining the MPS IIIA and MPS IIIB mice colony and laboratory consumables for research into the involvement of the blood brain barrier in MPS IIIA and MPS IIIB.

Dr James Edmond Wraith, Dr Rob Wynn & Dr Brian Bigger £64,886:Willink Biochemical Genetics Unit, Royal Manchester Children’s Hospital, England
Final year of a five year programme grant to establish the Stem Cell Therapy Group with funding for a Senior Research Fellow at the University of Manchester. The post-holder was to be responsible for establishing and leading a research group in stem cell therapy in inherited disorders of Mucopolysaccharide metabolism.

Prof Timothy Cox & Dr Patrick Deegan £32,000: Addenbrookes Hospital, University of Cambridge, England
Year one of an 18 month extension grant to establish what lies at the core of the difference between two x-linked lysosomal storage disorders, MPSII, Hunter disease, and Fabry disease, by determining why females harbouring one copy of the defective gene for MPSII almost never develop the condition, whereas females carrying a single Fabry disease gene nearly always suffer from the disorder.

Dr Brian Bigger £20,000: MPS Stem Cell Research Group, University of Manchester, UK
Second year of a two year grant for improving enzyme secretion and tracking in lentiviral mediated stem cell gene therapy of MPS III. NOTE: Made possible by a grant from the Irish MPS Society.

Dr Brian Bigger £6,500: MPS Stem Cell Research Group, University of Manchester, UK
Travel grant to the MPS Stem Cell Group.

Dr Chris Hendrickz £4,000: Birmingham Children’s Hospital, Birmingham, UK
Year two of a three year project looking at new imaging techniques and to develop appropriate assessment scales to measure cognitive decline by use of new psychological methods in children with lysosomal storage diseases.

2009

Dr Brian Bigger £20,000: MPS Stem Cell Research Group, University of Manchester, UK
First year of a two year grant for improving enzyme secretion and tracking in lentiviral mediated stem cell gene therapy of MPS III. NOTE: Made possible by a grant from the Irish MPS Society.

Dr Chris Hendrickz £4,000: Birmingham Children’s Hospital, Birmingham, UK
Year one of a three year project looking at new imaging techniques and to develop appropriate assessment scales to measure cognitive decline by use of new psychological methods in children with lysosomal storage diseases.

Professor Elsa Shapiro $49,500: University of Minnesota in Minneapolis USA
To investigate the cognitive, adaptive, quality of life and psycho-social outcomes of children who are at least one year post Haemopoietic Stem Cell Transplant for MPS IH, Hurler disease. This investigation will build upon the data collected in the Society’s previous three year psycho-social research project and result in publications.

Dr James Edmond Wraith, Dr Rob Wynn & Dr Brian Bigger £63,183: Willink Biochemical Genetics Unit, Royal Manchester Children’s Hospital, England
Year four of a five year programme grant to establish the Stem Cell Therapy Group with funding for a Senior Research Fellow at the University of Manchester. The post-holder was to be responsible for establishing and leading a research group in stem cell therapy in inherited disorders of Mucopolysaccharide metabolism.

Professor Bob Jolly £2,750: Massey University, Palmerston, North Island, New Zealand
One year grant to fund physiological principles underlying Intrathecal ERT in lysosomal storage diseases.

Dr Brian Bigger £6,500: MPS Stem Cell Research Group, University of Manchester, UK
Travel grant to the MPS Stem Cell Group.

2008

Prof Grzegorz Wegrzyn £40,000: University of Gdansk, Poland
Fourth year extension grant to develop “Gene Expression-Targeted Isoflavone Therapy (GET IT) for Mucopolysaccharidosis Type III, Sanfilippo disease”. The hypothesis was based on reducing the substrate, heparan sulphate, that cannot be degraded in lysosomes of affected patients due to a defect in one of the enzymes. NOTE: £20,000 funded by the UK MPS Society and the other £20,000 funded by ten international MPS Societies

Dr James Edmond Wraith, Dr Rob Wynn & Dr Brian Bigger £61,473: Willink Biochemical Genetics Unit, Royal Manchester Children’s Hospital, England
Year three of a five year programme grant to establish the Stem Cell Therapy Group with funding for a Senior Research Fellow at the University of Manchester. The post-holder was to be responsible for establishing and leading a research group in stem cell therapy in inherited disorders of Mucopolysaccharide metabolism.

Sarah Long Up to £5,000: University of Bath, Bath, England
‘Tipping the Lens’ was a participatory social documentary project enabling young people aged 11 years and over living with MPS IVA, Morquio disease, to develop their own narratives using their own words and visual images. The project involved staging an exhibition at the expert meeting on Morquio disease held in August 2008, writing up the research as part of the researcher’s academic studies and producing a DVD.

Jenny Noble £16,000: Lysosomal Storage Diseases New Zealand
A one-off grant to host an international consensus meeting for bone diseases in lysosomal storage diseases on the use of bisphosphonate therapy in Oligosaccharides held in Christchurch, New Zealand, 19-20 November 2008.

Dr Brian Bigger £33,625: MPS Stem Cell Group, University of Manchester
Year three of a three year grant fund a technician and part time PhD student to investigate non-myeloablative bone marrow transplantation for mucopolysaccharide diseases.

Dr Brian Bigger £20,000: MPS Stem Cell Group, University of Manchester
Year three of a three year grant to fund the costs of a PhD student to work on making cord blood transplant a safer way to treat those with MPS I Hurler and to develop methods in which the bone marrow can be used as a vehicle to transport missing genes into the bone and brain.

Dr Brian Bigger £30,000: MPS Stem Cell Group, University of Manchester
Matched funding with the University of Manchester towards a strategic studentship developing a lentiviral vector to deliver the missing enzyme to cells transplanted into mice with MPS III.

2007

Prof Timothy Cox & Dr Patrick Deegan £89,202: Addenbrookes Hospital, University of Cambridge, England
Final year of a three-year grant to establish what lies at the core of the difference between two x-linked lysosomal storage disorders, MPSII, Hunter disease, and Fabry disease, by determining why females harbouring one copy of the defective gene for MPSII almost never develop the condition, whereas females carrying a single Fabry disease gene nearly always suffer from the disorder.

Prof Grzegorz Wegrzyn £50,000: University of Gdansk, Poland
Final year of a three-year project to develop “Gene Expression-Targeted Isoflavone Therapy (GET IT) for Mucopolysaccharidosis Type III, Sanfilippo disease”. The hypothesis was based on reducing the substrate, heparan sulphate, that cannot be degraded in lysosomes of affected patients due to a defect in one of the enzymes.

Dr Brian Bigger £8,000: MPS Stem Cell Group, University of Manchester
Travel grant to the MPS Stem Cell Group.

Dr Brian Bigger £20,000: MPS Stem Cell Group, University of Manchester
Year two of a three year grant to fund the costs of a PhD student to work on making cord blood transplant a safer way to treat those with MPS I Hurler and to develop methods in which the bone marrow can be used as a vehicle to transport missing genes into the bone and brain.

Dr Brian Bigger £30,000MPS Stem Cell Group, University of Manchester
Year two of a three year grant fund a technician and part time PhD student to investigate non-myeloablative bone marrow transplantation for mucopolysaccharide diseases.

Dr James Edmond Wraith, Dr Rob Wynn & Dr Brian Bigger £60,418: Willink Biochemical Genetics Unit, Royal Manchester Children’s Hospital, England
Year two of a five year programme grant to establish the Stem Cell Therapy Group with funding for a Senior Research Fellow at the University of Manchester. The post-holder was to be responsible for establishing and leading a research group in stem cell therapy in inherited disorders of Mucopolysaccharide metabolism.

2006

Dr Brian Bigger £111,750: MPS Stem Cell Group, University of Manchester
The identification of stem cell populations with a capacity to compliment the major deficiencies in MPS diseases.

Dr Brian Bigger £20,000; MPS Stem Cell Group, University of Manchester
Year one of a three year grant to fund the costs of a PhD student to work on making cord blood transplant a safer way to treat those with MPS I Hurler and to develop methods in which the bone marrow can be used as a vehicle to transport missing genes into the bone and brain.

Prof Timothy Cox & Dr Patrick Deegan £70,912: Addenbrookes Hospital, University of Cambridge, England
Year two of a three-year grant to establish what lies at the core of the difference between two x-linked lysosomal storage disorders, MPSII, Hunter disease, and Fabry disease, by determining why females harbouring one copy of the defective gene for MPSII almost never develop the condition, whereas females carrying a single Fabry disease gene nearly always suffer from the disorder.

Prof Grzegorz Wegrzyn £50,000; University of Gdansk, Poland
Year two of a three-year project to develop “Gene Expression-Targeted Isoflavone Therapy (GET IT) for Mucopolysaccharidosis Type III, Sanfilippo disease”. The hypothesis was based on reducing the substrate, heparan sulphate, that cannot be degraded in lysosomes of affected patients due to a defect in one of the enzymes.

Dr James Edmond Wraith, Dr Rob Wynn & Dr Brian Bigger £59,008: Willink Biochemical Genetics Unit, Royal Manchester Children’s Hospital, England
Year one of a five year programme grant to establish the Stem Cell Therapy Group with funding for a Senior Research Fellow at the University of Manchester. The post-holder was to be responsible for establishing and leading a research group in stem cell therapy in inherited disorders of Mucopolysaccharide metabolism.

Dr Brian Bigger £30,000; MPS Stem Cell Group, University of Manchester
Year one of a three year grant fund a technician and part time PhD student to investigate non-myeloablative bone marrow transplantation for mucopolysaccharide diseases.